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Advancements in Stem Cell Therapy for Kidney Failure

Advancements in Stem Cell Therapy for Kidney Failure

India has the second highest number of chronic kidney diseases (CKD) cases in the world, with the debilitating condition affecting over 1 lakh Indians every year. Given the limitations of traditional therapies such as dialysis and kidney transplantation, researchers are turning to innovative approaches like stem cell therapy for symptom management, renal revival, and improved quality of life.

At Plexus, we offer the most advanced stem cell therapy for kidney failure in India.

This blog delves into the intricacies of stem cell therapy for kidney failure.

Understanding Kidney Failure

Kidney failure, also known as end-stage renal disease (ESRD), refers to a severe and often irreversible loss of kidney function. The kidneys play a vital role in maintaining overall health by filtering waste products, excess fluids, and toxins from the blood, regulating electrolyte levels, and producing hormones that help control blood pressure and stimulate red blood cell production.

Kidney failure occurs when the kidneys are no longer able to perform these essential functions adequately. 

This can result from various underlying conditions, including:

  • Chronic Kidney Disease (CKD): CKD is a progressive condition characterized by gradual loss of kidney function over time. Common causes include diabetes, high blood pressure, autoimmune diseases, and genetic disorders. As CKD advances, kidney function declines, eventually leading to kidney failure if left untreated.

Read about the 5 stages of CKD here.

  • Acute Kidney Injury (AKI): AKI is a sudden and severe decrease in kidney function that typically occurs over a short period. It can result from factors such as dehydration, infections, medication toxicity, severe blood loss, or kidney damage due to trauma. While AKI may be reversible with prompt treatment, severe cases can progress to kidney failure.

Symptoms of Kidney Failure

The following are the most common symptoms of kidney failure: 

  • Fatigue
  • Swelling in the legs, ankles, or feet
  • Decreased urine output or dark-colored urine
  • Shortness of breath
  • Nausea and vomiting
  • Confusion or difficulty concentrating
  • Persistent itching
  • Muscle cramps or weakness

Diagnosis of kidney failure involves blood tests to assess kidney function, urine tests to check for protein or blood in the urine, as well as imaging studies such as ultrasound or CT scans. In some cases, a kidney biopsy may be done to evaluate tissue damage.

Mesenchymal Stem Cell Therapy for Kidney Failure in India

Mesenchymal stem cells (MSCs), derived from sources such as bone marrow or adipose tissue, are among the most widely studied cell types for kidney regeneration. These cells possess anti-inflammatory, immunomodulatory, and tissue-repairing properties and offer the following benefits when used for treatment of kidney failure:

  • Stem cells can differentiate into various cell types found in the kidney, including tubular epithelial cells and endothelial cells, promoting tissue repair and regeneration. 
  • They secrete growth factors that stimulate tissue repair and regeneration. 
  • They reduce inflammation and prevent further damage to the kidneys by modulating immune response.

If you wish to know more about Plexus’ stem cell therapy for kidney diseases, please reach out to our centres in Bangalore and Hyderabad today.

WhatsApp +91 89048 42087

Call +91 78159 64668 (Hyderabad) | +91 82299 99888 (Bangalore)


Can stem cells cure kidney failure?

Stem cell therapy aims to improve kidney function, reduce symptoms, and potentially delay disease progression by promoting tissue repair and regeneration.

Can a damaged kidney regenerate?

The human kidney has limited regenerative capacity and can repair minor damage. However, severe or chronic damage can impact its ability to regenerate fully.

Has anyone recovered from CKD?

Some individuals with CKD may experience improved kidney function and quality of life with appropriate management, including regenerative medicine like stem cell therapy, prescription medication, lifestyle changes, and dialysis. However, complete recovery from advanced stages of CKD, such as stages 4 and 5, are rare.

Can you reverse stage 4 kidney failure?

Complete reversal of stage 4 kidney failure is unlikely. However, with certain lifestyle modifications, regular follow up treatment and therapy,  it may be possible to slow or stabilize the progression of stage 4 kidney failure. 

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