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Fulminant multiple sclerosis

Fulminant multiple sclerosis

Fulminant multiple sclerosis or Marburg sclerosis is the most severe form of multiple sclerosis. It results in the rapid deterioration of the myelin sheath around the neurons. Although rare, the symptoms of Fulminant multiple sclerosis can be managed through regenerative rehabilitation.

As India’s first ISO-certified stem cell research center, Plexus Bangalore offers the best treatment for Fulminant Multiple Sclerosis through stem cell therapy and regenerative care.

Understanding Multiple Sclerosis?

Multiple Sclerosis (MS) is an autoimmune, neurodegenerative and inflammatory condition  that attacks the central nervous system. MS disrupts the working of a healthy immune system, and quite literally turns it into the body’s villain.  It makes the immune system work against the body. A healthy immune system protects the body from infections. However, MS causes the immune system to attack the body’s own tissues.

Fulminant Multiple Sclerosis

MS is a demyelinating disorder of the central nervous system (CNS). It is caused by the breakage in the myelin sheath (a thin layer that covers the axons of the neuron). When the myelin along with the nerve fibers are attacked and destroyed, scar tissue (lesions) disrupts the communication routes between the CNS and the rest of the body.

The term ‘fulminant’ implies severe and sudden in onset.

In Fulminant MS the demyelination is rapid and the lesions are more widespread. It is similar to relapsing-remitting multiple sclerosis (RRMS). It can also involve the peripheral nervous system, cause extensive tissue destruction, axonal damage, and necrosis (death of body tissue).

The first diagnosis of Fulminant MS was made by Austrian neurologist Otto Marburg in 1906. This is why this variant is also called Marburg Sclerosis.

Symptoms of Fulminant Multiple Sclerosis

Since Fulminant MS progresses rapidly, the below symptoms are major red flags and their persistent presentation needs to be assessed by a doctor immediately. 

  • Tingling or numbness in hands and/or feet
  • Spasticity or stiffness
  • Vision troubles like double vision or temporary blindness
  • Fatigue and weakness
  • Bladder control problems
  • Cognitive impairment and severe confusion
  • Seizures
  • Motor aphasia (inability to talk)
  • Quadriplegia (inability to move arms and legs)

Most of these symptoms appear suddenly and without warning, making it difficult for the patient to make sense of what is going on. As the disease advances and the symptoms intensify, the patient may also experience more relapse episodes and quick deterioration of their physical and neurological functioning in a short span of time.

Risks and causes of Fulminant Multiple Sclerosis

Like other MS variants, Fulminant MS’ cause also remains relatively unknown and difficult to pinpoint. Scientists and doctors believe that Fulminant MS may be caused by a combination of environmental and genetic factors that makes individuals more and more susceptible to the condition. 

Fulminant MS primarily affects young adults and children. It progresses at a drastic rate causing significant decline in motor function, flexibility, mental health, and other symptoms.


Depending on the severity of symptoms presented, your doctor may ask for any or all of the following tests to be carried out prior to confirming a Fulminant MS diagnosis.

  • MRI – to get a clear picture of lesions and their progression
  • Spinal tap (lumbar puncture) – to examine cerebrospinal fluid
  • Blood tests
  • Nerve function tests

Since the symptoms of Fulminant multiple sclerosis are similar to other neurological conditions, a neurosurgeon may even perform a brain biopsy to arrive at a conclusive diagnosis.


Regenerative medicine has proved to be effective in treating patients with MS. And even as we speak, extensive research and trials are being conducted across the world, moving us closer to a cure.

Until then, we have to manage our symptoms of MS, especially Fulminant MS through – 

  • Regenerative treatment, like stem cell therapy
  • Corticosteroids
  • Immunoglobulin therapy
  • Plasma exchange
  • Chemotherapy
  • Immunomodulators

Nearly every article on the internet will be the bearer of grim news if you were to search for the life expectancy of a patient with Fulminant MS or Marburg Sclerosis. And that is why we urge you to alter your search instead. Look for Plexus Multiple Sclerosis Rehabilitation

Regenerative rehabilitation at Plexus

Founded by Dr. Na’eem Sadiq, India’s foremost and award-winning neurologist, Plexus’ MS rehabilitation program follows a tailored treatment approach. Through our program we instill hope in individuals with Fulminant MS as well as significantly improve their quality of life. Our team of expert doctors and therapists with a combined clinical experience of over 35 years will customize a rehabilitation plan that will – 

  • Manage your symptoms
  • Improve day-to-day functionality
  • Enable you to participate actively in your daily activities and work

Our MS rehabilitation program comprises:

  • Stem cell therapy
  • Activities for daily living training
  • Cognitive retraining
  • Functional strengthening
  • Motor relearning program
  • Splinting for weak muscles
  • Gait training
  • Balance training
  • Coordination training
  • Fall prevention training
  • Hand function training
  • Speech therapy

Through this program, our patients have experienced – 

  • Enhanced strength, flexibility, coordination, and general fitness
  • The joy of learning new skills
  • Improved mobility
  • More independence in daily activities
  • Improved cognitive function
  • Improved mental health

Even if there is the slightest sliver of hope when it comes to Fulminant Multiple Sclerosis, we should grab it, shouldn’t we?

To book an appointment, please call us on:

+91 89048 42087 | 080-2546 0886

080-2547 0886 | 080-2549 0886


How common is fulminant MS?

Less than 25 cases of Fulminant MS have been reported worldwide since its discovery in 1906.

How fast does fulminant MS progress?

Fulminant MS advances rapidly leading to death within a year of diagnosis.

What is the most severe type of MS?

Fulminant MS or Marburg Sclerosis is the most severe variant of MS causing rapid demyelination of the CNS, leading to severe disability and death within weeks/months of diagnosis.

What are the final stages of MS?

The final stages of MS involve breathing difficulties, mobility issues, speech troubles, severe muscle spasms, and mental health complications like depression, anxiety, etc.

What is the rare aggressive form of MS?

Tumefactive sclerosis is the most aggressive form of MS.

How long can a patient live with MS?

Unless the individual has a rare and/or aggressive form of MS, they can continue to live a purposeful life with treatment that improves their quality of life.

What does MS do to your organs?

Since, MS causes the immune system to attack the central nervous system, it can lead to deterioration of other organs. MS can cause bladder and bowel dysfunction, sexual problems, cognitive and mood changes such as depression, vision disruption, and more.

What is the most common cause of death in MS?

Respiratory infection is the most common cause of death in MS.

Can MS be cured?

Each day we move closer and closer to finding a cure for MS. However, until then the only course of treatment is managing the symptoms and delaying the progression as much as possible and improving the quality of life of patients suffering from MS.

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